PAR2 (D61D5) Rabbit Monoclonal Antibody#6976,Cell Signaling Technology (CST),6976

PAR2 (F2RL1) belongs to the PAR (Protease-activated Receptor) family of G protein-coupled receptors. These membrane receptors are activated through N-terminal cleavage of the receptor by a serine protease such as thrombin, trypsin, or matrix metalloproteinases (1,2). This cleavage exposes the ‘tethered-ligand’ fragment of the receptor, which binds to a second extracellular loop of the receptor and leads to receptor activation. PAR2 is specifically activated by trypsin or trypsin-like proteases. Activated PAR2 stimulates phosphoinositide hydrolysis and calcium mobilization, interacts with β-arrestin, and eventually leads to ERK activation (3). PAR2 expression and activation are mainly associated with inflammatory diseases (3), but may also play a role in cancer development (4,5).Macfarlane, S.R. et al. (2001)Pharmacol Rev53, 245-82.Ossovskaya, V.S. and Bunnett, N.W. (2004)Physiol Rev84, 579-621.Bushell, T. (2007)J Physiol581, 7-16.Su, S. et al. (2009)Oncogene28, 3047-57.Gessler, F. et al. (2010)Neuroscience165, 1312-22.Alternate Namescoagulation factor II (thrombin) receptor-like 1; Coagulation factor II receptor-like 1; F2R like trypsin receptor 1; F2RL1; G protein-coupled receptor-11; G-protein coupled receptor 11; GPR11; PAR-2; PAR2; protease-activated receptor 2; Proteinase-activated receptor 2; Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2; proteinase-activated receptor-2; Thrombin receptor-like 1

coagulation factor II (thrombin) receptor-like 1; Coagulation factor II receptor-like 1; F2R like trypsin receptor 1; F2RL1; G protein-coupled receptor-11; G-protein coupled receptor 11; GPR11; PAR-2; PAR2; protease-activated receptor 2; Proteinase-activated receptor 2; Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2; proteinase-activated receptor-2; Thrombin receptor-like 1