PARP1 Rabbit mAb,ABclonal,A27791

Reactivity

Human, Mouse, Rat

Application

WB, IF/ICC, IF-P, IHC-P, ELISA

Conjugate

Unconjugated

Platform ID

BAB658052243

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePARP1 Rabbit mAb
Cat. No.A27791
Accession NumberP09874
Gene ID (Entrez)142
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB, IF/ICC, IF-P, IHC-P, ELISA
Working DilutionsWB:1:13000 - 1:52000 | IF/ICC:1:200 - 1:600 | IF-P:1:200 - 1:600 | IHC-P:1:200 - 1:800 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Clone NumberARC74063
Molecular Weight89kDa(cleaved)/116kDa(Full-length)
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Synonyms

PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP

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