PD-L1 (6C8) Monoclonal Antibody,Bioss,bsm-58003R

Host

Rabbit

Reactivity

Human

Application

WB, FCM

Conjugate

Unconjugated

Platform ID

BAB659405156

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePD-L1 (6C8) Monoclonal Antibody
Cat. No.bsm-58003R
Accession NumberQ9NZQ7
Gene ID (Entrez)29126
HostRabbit
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB, FCM
Working DilutionsWB:1:300-5000 | FCM:1:20-100
ClonalityMonoclonal
ConcentrationNot Determined
PurityPurified by Protein A.
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageStore at -20C for 12 months.

Scientific Background

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077).

Synonyms

Programmed cell death 1 ligand 1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1; Programmed death ligand 1

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.