PD-L1 (Extracellular Domain Specific) (D8T4X) Rabbit Monoclonal Antibody (Alexa Fluor^®488 Conjugate)#25048,Cell Signaling Technology (CST),25048

Programmed cell death 1 ligand 1 (PD-L1, B7-H1, CD274) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. The PD-L1 ligand binds the PD-1 transmembrane receptor and inhibits T cell activation. PD-L1 was discovered following a search for novel B7 protein homologs and was later shown to be expressed by antigen presenting cells, activated T cells, and tissues including placenta, heart, and lung (1-3). Similar in structure to related B7 family members, PD-L1 protein contains extracellular IgV and IgC domains and a short, cytoplasmic region. Research studies demonstrate that PD-L1 is expressed in several tumor types, including melanoma, ovary, colon, lung, breast, and renal cell carcinomas (4-6). Expression of PD-L1 in cancer is associated with tumor-infiltrating lymphocytes, which mediate PD-L1 expression through the release of interferon gamma (7). Additional research links PD-L1 expression to cancers associated with viral infections (8,9).Dong, H. et al. (1999)Nat Med5, 1365-9.Freeman, G.J. et al. (2000)J Exp Med192, 1027-34.Liang, S.C. et al. (2003)Eur J Immunol33, 2706-16.Dong, H. et al. (2002)Nat Med8, 793-800.Thompson, R.H. et al. (2006)Cancer Res66, 3381-5.Pardoll, D.M. (2012)Nat Rev Cancer12, 252-64.Taube, J.M. et al. (2012)Sci Transl Med4, 127ra37.Lyford-Pike, S. et al. (2013)Cancer Res73, 1733-41.Chen, B.J. et al. (2013)Clin Cancer Res19, 3462-73.Alternate NamesB7 homolog 1; B7-H; B7-H1; B7H1; CD274; CD274 antigen; CD274 molecule; hPD-L1; MGC142294; MGC142296; PD-L1; PD1L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; Programmed cell death 1 ligand 1; Programmed death ligand 1

B7 homolog 1; B7-H; B7-H1; B7H1; CD274; CD274 antigen; CD274 molecule; hPD-L1; MGC142294; MGC142296; PD-L1; PD1L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; Programmed cell death 1 ligand 1; Programmed death ligand 1