PE Anti-BSND antibody [EPR14270] - C-terminal,Abcam,AB320224

Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . How are conjugated primary antibodies validated? This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling. For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

Antibody Labelling, IHC-P, Target Binding Affinity

Conjugate

PE

Platform ID

BAB232898713

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NamePE Anti-BSND antibody [EPR14270] - C-terminal
Cat. No.AB320224
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationPE
ApplicationAntibody Labelling, IHC-P, Target Binding Affinity
ClonalityMonoclonal
Clone NumberEPR14270
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Regulatory subunit of anion-selective CLCNKA : BSND and CLCNKB : BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (PubMed : 11734858, PubMed : 12111250, PubMed : 12574213, PubMed : 16849430, PubMed : 18776122, PubMed : 19646679, PubMed : 20538786, PubMed : 26013830). Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA : BSND and CLCNKB : BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates (PubMed : 11734858, PubMed : 12111250, PubMed : 12574213, PubMed : 16849430, PubMed : 18776122, PubMed : 19646679, PubMed : 20538786, PubMed : 26013830). See full target information BSND

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