PE Anti-Bcl-XL antibody [E18],Abcam,AB208747
What is this antibody validated in? PE Anti-Bcl-XL antibody [E18] (ab208747) is a rabbit recombinant monoclonal antibody and is validated for use in Flow Cytometry (Intra), Flow Cytometry (Flow Cyt) in Human samples. Related products Antibody clone E18 is also available pre-conjugated to a variety of labels for your convenience – Anti-Bcl-XL PE [E18] (ab208747). Other related products We have a range of other formats of antibody clone [E18] also available for your convenience: ab32370 , Carrier free - ab199099 , HRP - ab200600 , PE - ab208747, Alexa Fluor® 647 - ab303457 , Alexa Fluor® 555 - ab306571 , Alexa Fluor® 750 - ab321595 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents .
Host
Rabbit
Reactivity
Mouse, Rat, Human, Human, Mouse, Rat
Application
ICC/IF, Flow Cyt, Flow Cyt (Intra), IHC-P
Conjugate
PE
Platform ID
BAB670267526
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed : 17418785).. Isoform Bcl-X(S) promotes apoptosis. See full target information BCL2L1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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