PE Anti-CCR3 antibody [5E8],Abcam,AB233070

Target data G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines (PubMed : 28994588). Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26 (PubMed : 7622448, PubMed : 8642344, PubMed : 8676064). Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis (PubMed : 18406577). Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway (PubMed : 8676064, PubMed : 35570218). May also act as a possible functional receptor for NARS1 (PubMed : 30171954).. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. See full target information CCR3