PE Anti-Integrin beta 4 antibody [346-11A],Abcam,AB216310

Host

Rat

Reactivity

Mouse

Application

Flow Cyt

Conjugate

PE

Platform ID

BAB676364598

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NamePE Anti-Integrin beta 4 antibody [346-11A]
Cat. No.AB216310
HostRat
IsotypeIgG2a
ReactivityMouse
ConjugationPE
ApplicationFlow Cyt
ClonalityMonoclonal
Clone Number346-11A
Concentration0.2 mg/mL Batch dependent concentration
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6 : ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6 : ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6 : ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling. See full target information Integrin beta-4

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