PE Anti-Nicastrin antibody [002],Abcam,AB275621

Host

Rabbit

Reactivity

Human

Application

Flow Cyt

Conjugate

PE

Platform ID

BAB677863878

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NamePE Anti-Nicastrin antibody [002]
Cat. No.AB275621
HostRabbit
IsotypeIgG
ReactivityHuman
ConjugationPE
ApplicationFlow Cyt
ClonalityMonoclonal
Clone Number002
Concentration0.1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human NCSTN aa 1-700. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.09% Sodium azide Constituents: 0.5% BSA
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed : 10993067, PubMed : 12679784, PubMed : 25043039, PubMed : 26280335, PubMed : 30598546, PubMed : 30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. See full target information NCSTN

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