PE Anti-P Glycoprotein antibody [UIC2],Abcam,AB93590

ab93590 has been reported to inhibit MDR1-mediated efflux.

Host

Mouse

Reactivity

Human

Application

Flow Cyt

Conjugate

PE

Platform ID

BAB178113758

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NamePE Anti-P Glycoprotein antibody [UIC2]
Cat. No.AB93590
HostMouse
IsotypeIgG2a
ReactivityHuman
ConjugationPE
ApplicationFlow Cyt
ClonalityMonoclonal
Clone NumberUIC2
Concentration0.1 mg/mL Batch dependent concentration
ImmunogenCell preparation containing ABCB1 protein. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.09% Sodium azide
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Translocates drugs and phospholipids across the membrane (PubMed : 2897240, PubMed : 35970996, PubMed : 8898203, PubMed : 9038218, PubMed : 35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed : 8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed : 2897240, PubMed : 35970996, PubMed : 9038218). See full target information ABCB1

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