PE/Cy5® Anti-IL3RA/CD123 antibody [6H6],Abcam,AB232697

This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5, 268, 486 and related patents. Cy® and CyDye® are trademarks of Cytiva.

Host

Mouse

Reactivity

Human

Application

Flow Cyt

Conjugate

PE/Cy5®

Platform ID

BAB610784827

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NamePE/Cy5® Anti-IL3RA/CD123 antibody [6H6]
Cat. No.AB232697
HostMouse
IsotypeIgG1
ReactivityHuman
ConjugationPE/Cy5®
ApplicationFlow Cyt
ClonalityMonoclonal
Clone Number6H6
ImmunogenCell preparation containing IL3RA protein. The exact immunogen used to generate this antibody is proprietary information.
PuritySize-exclusion chromatography
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed : 10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity). See full target information IL3RA

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