PE/Cyanine5 anti-HDAC1 Phospho (Ser406) Antibody, HDAC1 Phospho (Ser406), BT-15,BioLegend,611008

When tested for western blot, this clone produced a band that showed a ~1-3 kD mass shift compared to a pan HDAC1 antibody. This observation is consistent with a previous study of the HDAC1 Phospho (Ser406) site.This clone recognizes zebrafish HDAC1 phosphorylated at Ser4062.Clone BT-15 cross-reacts to Zebrafish2

Host

Mouse

Reactivity

Human, Zebrafish

Application

ICFC - Quality tested

Platform ID

BAB523716755

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

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Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePE/Cyanine5 anti-HDAC1 Phospho (Ser406) Antibody, HDAC1 Phospho (Ser406), BT-15
Cat. No.611008
HostMouse
RRIDAB_2910486 (BioLegend Cat. No. 611007)AB_2910486 (BioLegend Cat. No. 611008)
IsotypeMouse IgG2b, κ
ReactivityHuman, Zebrafish
ApplicationICFC - Quality tested
ClonalityMonoclonal
Clone NumberBT-15
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetHDAC1 Phospho Ser406
ImmunogenSynthetic peptide corresponding to human HDAC1 phosphorylated at Serine 406
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Cyanine5 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Histone Deacetylase 1 (HDAC1) plays a critical role in various cellular processes, including cell cycle progression, proliferation, and differentiation. The enzyme functions by removing acetyl moieties from histone targets, resulting in histone compaction and alterations in nucleosomal positioning.  Aurora kinases phosphorylate HDAC1 at Ser406 during prophase, immediately after cells begin mitosis, resulting in reduced deacetylase activity of HDAC1. This modification plays an essential role in regulating cell cycle progression, as well as controlling the expression of genes involved in central nervous system development.

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