PE/Cyanine7 anti-human CD117 c-kit Antibody anti-CD117 - A3C6E2,BioLegend,323414

Additional reported applications (for the relevant formats) include: Blocking the binding of SCF. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/μg, Azide-Free, 0.2 μm filtered) is recommended for functional assays (Cat. No. 323417 & 323418).

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB890308293

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NamePE/Cyanine7 anti-human CD117 c-kit Antibody anti-CD117 - A3C6E2
Cat. No.323414
HostMouse
RRIDAB_755984 (BioLegend Cat. No. 323414)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberA3C6E2
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD117
ImmunogenMOLM-1 megakaryocitic cell line
PurityThe antibody was purified by affinity chromatography, and conjugated with PE/Cyanine7 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD117 is a 145 kD protein tyrosine kinase also known as c-kit. It is a receptor for stem cell factor or c-kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemic cells (AML). CD117 binding of c-kit ligand induces phosphorylation of CD117, and stimulates proliferation and survival of primitive hematopoietic stem cells as well as erythroid-committed and granulo-monocytic committed cells. The A3C6E2 antibody potently blocks the binding of SCF.

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