PE/Cyanine7 anti-human CD307cFcRL3 Antibody anti-CD307cFcRL3 - H5FcRL3,BioLegend,374410
Host
Mouse
Reactivity
Human
Application
FC -Quality tested
Platform ID
BAB352665106
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePE/Cyanine7 anti-human CD307cFcRL3 Antibody anti-CD307cFcRL3 - H5FcRL3
Cat. No.374410
HostMouse
RRIDAB_2728395 (BioLegend Cat. No. 374409)AB_2728396 (BioLegend Cat. No. 374410)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone NumberH5/FcRL3
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD307c/FcRL3
ImmunogenFcRL3 full length expression plasmid DNA, followed by cell boost using transiently transfected cells with the same plasmid.
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD307c is a type 1 transmembrane glycoprotein in the FcRL family of the Ig gene superfamily that is conserved in humans and not found in mice. It is expressed on NK cells, T cell, regulatory T cell, B cell and plasma cell subsets. Intracellular ITAM and ITIM motifs in conjunction with extracellular Ig domains are thought to play a role in the regulation of immune response, and autoimmune function. Impairment of normal FcRL3 function has been linked to systemic lupus erythematosus, rheumatoid arthritis, and autoimmune thyroid disease.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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