PE/Cyanine7 anti-human Ikaros Antibody anti-Ikaros - 16B5C71,BioLegend,368413
There are eight splicing variants with predicted MW 58, 53, 48(2), 43, 41, 31, 24 KDa. This antibody might recognize some of the isoforms.
Host
Mouse
Reactivity
Human
Application
ICFC -Quality tested
Platform ID
BAB981164661
BioLegend
Contact
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Product Specifications
Scientific Background
Specifications
NamePE/Cyanine7 anti-human Ikaros Antibody anti-Ikaros - 16B5C71
Cat. No.368413
HostMouse
RRIDAB_2734415 (BioLegend Cat. No. 368413)AB_2734416 (BioLegend Cat. No. 368414)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationICFC -Quality tested
ClonalityMonoclonal
Clone Number16B5C71
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetIkaros
ImmunogenHuman Ikaros peptide (431-477 aa) conjugated to KLH Freund's adjuvant.
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
Ikaros, also known as IKZF1, belongs to a family of zinc-finger DNA-binding proteins that regulate lymphocyte differentiation. It has the ability to form homo- and heterodimers with other members of the Ikaros family, which include Aiolos and Helios. Ikaros can be found on a majority of fetal and adult hematopoietic cell types such as T- and B-cells, natural killer cells (NKs), monocytes/macrophages, and dendritic cells. Ikaros is a tumor suppressor and its absence or reduced expression has been reported in several leukemias.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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