PE/Cyanine7 anti-mouse CD172a SIRPalpha Antibody anti-CD172a - P84,BioLegend,144008
Additional reported applications (for the relevant formats) include: blocking SIRPa interaction with CD474,in vivoblocking of dendritic cell migration3, enhancing of macrophage phagocytosis2,4, immunohistochemical staining of cerebellum frozen sections1, immunoprecipitation2,4, and spatial biology (IBEX)5,6.
Host
Rat
Reactivity
Mouse
Application
FC - Quality tested
Platform ID
BAB515509432
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePE/Cyanine7 anti-mouse CD172a SIRPalpha Antibody anti-CD172a - P84
Cat. No.144008
HostRat
RRIDAB_2563545 (BioLegend Cat. No. 144007)AB_2563546 (BioLegend Cat. No. 144008)
IsotypeRat IgG1, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberP84
Concentration0.2 mg/ml
TargetCD172alpha
ImmunogenMouse brain membrane protein
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD172a, also known as SIRPα, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. The phosphorylation of SIRPα ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 and PTPN11, resulting in the negative regulation of several biological processes. The ligands of CD172a are CD47, SP-A, and SP-D.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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