PE/Cyanine7 anti-mouse CD226 DNAM-1 Antibody anti-CD226 - 10E5,BioLegend,128812
Host
Rat
Reactivity
Mouse
Application
FC - Quality tested
Platform ID
BAB037871222
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
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Product Specifications
Scientific Background
Specifications
NamePE/Cyanine7 anti-mouse CD226 DNAM-1 Antibody anti-CD226 - 10E5
Cat. No.128812
HostRat
RRIDAB_2566628 (BioLegend Cat. No. 128811)AB_2566629 (BioLegend Cat. No. 128812)
IsotypeRat IgG2b, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number1000000
Concentration0.2 mg/ml
TargetCD226
ImmunogenTh1 polarized T cell clones
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD226 (DNAM-1) is constitutively expressed on native CD8+cells and on CD4+T cells, macrophages and NK cells.This antibody (10E5) was reported to bind about 40% of inactivated CD4+cells and binds only to differentiated Th1 cells, but not to Th2 or Th0 cells.It is also reported to suppress antigen-specific T cell expansion and EAE (experimental allergic encephalitis) mediated by Th1 cells.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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