PE/Cyanine7 anti-mouse CD253 TRAIL Antibody anti-CD253 - N2B2,BioLegend,109312
Additional reported applications (for the relevant formats) include:in vitroblocking of NK cell cytotoxicity1,2. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 109308).
Host
Rat
Reactivity
Mouse
Application
FC -Quality tested
Platform ID
BAB071044027
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePE/Cyanine7 anti-mouse CD253 TRAIL Antibody anti-CD253 - N2B2
Cat. No.109312
HostRat
RRIDAB_2721675 (BioLegend Cat. No. 109311)AB_2721676 (BioLegend Cat. No. 109312)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone NumberN2B2
Concentration0.2 mg/ml
TargetCD253
ImmunogenMouse TRAIL-transfected 2PK-3 cells
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD253 is a 40 kD TNF superfamily member known as TRAIL, Apo-2 ligand, and Apo-2L. TRAIL is expressed on a variety of cells, including IL-2 and IL-15 activated NK cells and activated T cells. However, it is undetectable on resting T and B cells. TRAIL has been reported to induce apoptosis in tumor and transformed cell lines by a caspase-dependent process. The N2B2 antibody has been reported to be useful for flow cytometric staining and blocking NK cell cytotoxicityin vitro.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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