PE/Cyanine7 anti-mouse DR3 TNFRSF25 Antibody anti-DR3 - 4C12,BioLegend,144410

4C12 is an agonistic antibody. It leads to rapid and selective proliferation of pre-existing Tregsin vivothrough TCR engagement with MHC class II (MHC-II) and IL-2 signaling. We recommend our Ultra-LEAF™ purified 4C12 antibody (Cat. No. 144411 and 144412) for agonist orin vivostudies.

Host

Armenian Hamster

Reactivity

Mouse

Application

FC -Quality tested

Platform ID

BAB186022604

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePE/Cyanine7 anti-mouse DR3 TNFRSF25 Antibody anti-DR3 - 4C12
Cat. No.144410
HostArmenian Hamster
RRIDAB_2734205 (BioLegend Cat. No. 144409)AB_2734206 (BioLegend Cat. No. 144410)
IsotypeArmenian Hamster IgG
ReactivityMouse
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone Number4C12
Concentration0.2 mg/ml
TargetDR3
ImmunogenMtnfr25-Ig fusion protein
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

DR3, also known as TNFRSF25, lymphocyte-associated receptor of death (LARD), WSL-1, TRAMP, TR3 and APO3, is a 55 kD glycoprotein belonging to the TNF receptor superfamily (TNFRSF). TNFSF25 is expressed at low level on CD4-positive, CD8-positive T cells and NKT cells. It has been shown to stimulate NF-κB activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domains containing adaptor proteins. Recently, it has been shown that TNFRSF25 is also expressed on Treg cells and regulates Treg proliferation.

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