PE/Dazzle™ 594 anti-human CD273 B7-DC PD-L2 Antibody, CD273, MIH18,BioLegend,345517

Additional reported applications (for the relevant formats) include: blocking4,5, and immunohistochemistry in frozen sections2and paraffin-embedded formalin-fixed sections6. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 345504).

Host

Mouse

Reactivity

Human

Application

FC -Quality tested

Platform ID

BAB316871031

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Product Specifications
Scientific Background

Specifications

NamePE/Dazzle™ 594 anti-human CD273 B7-DC PD-L2 Antibody, CD273, MIH18
Cat. No.345517
HostMouse
RRIDAB_2750475 (BioLegend Cat. No. 345517)AB_2750476 (BioLegend Cat. No. 345518)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone NumberMIH18
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD273
ImmunogenHuman B7-DC transfected cells
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD273, known as B7-DC, is also called programmed death ligand 2 (PDL2). This ligand is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily and is expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. CD273 has been reported to be stimulatory on dendritic cells when cross-linked and to inhibit T cell activation upon engaging the PD-1 receptor. CD273 has also been reported to bind to an alternative receptor and to mediate T cell activation through such non-PD1 mediated interactions. Clone MIH18 is reported to block PDL2.

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