PE/Dazzle™ 594 anti-mouse CD366 (Tim-3) Antibody, CD366, RMT3-23,BioLegend,119748

Additional reported applications (for relevant formats) include:in vitro1andin vivo2blocking of Tim-3, and immunohistochemical staining of frozen sections2. The Ultra-LEAF™ purified antibody (Endotoxin <0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 119731-119736).

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB836611551

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NamePE/Dazzle™ 594 anti-mouse CD366 (Tim-3) Antibody, CD366, RMT3-23
Cat. No.119748
HostRat
RRIDAB_2924459 (BioLegend Cat. No. 119747)AB_2924459 (BioLegend Cat. No. 119748)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberRMT3-23
Concentration0.2 mg/mL
TargetCD366
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on Th1 lymphocytes and CD11b+macrophages. Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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