PE/Dazzle™ 594 anti-mouse CD49d Antibody anti-CD49d - R1-2,BioLegend,103626
The R1-2 antibody has been shown to partially block CD49d mediated interactions and, in combination with the 9C10 (MFR4.B) antibody, completely blocks VCAM-1 binding to VLA-4. Additional reported applications (for the relevant formats) include:in vitroandin vivoblocking of cell-cell adhesion and T cell costimulation1-4, immunoprecipitation1, and immunohistochemistry of frozen sections5. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No.103629 and 103630).
Host
Rat
Reactivity
Mouse
Application
FC -Quality tested
Platform ID
BAB645769406
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePE/Dazzle™ 594 anti-mouse CD49d Antibody anti-CD49d - R1-2
Cat. No.103626
HostRat
RRIDAB_2734160 (BioLegend Cat. No. 103625)AB_2734161 (BioLegend Cat. No. 103626)
IsotypeRat IgG2b, κ
ReactivityMouse
ApplicationFC -Quality tested
ClonalityMonoclonal
Clone NumberR1-2
Concentration0.2 mg/ml
TargetCD49d
ImmunogenAKR/Cum mouse spontaneous T lymphoma line TK1
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD49d is a 150 kD glycoprotein, also known as α4integrin or VLA-4 α chain. It is a member of the integrin family, expressed on T and B cells, monocytes, eosinophils, basophils, mast cells, thymocytes, NK cells, and dendritic cells. CD49d is a heterodimer expressed with either of two β chains, β1 (CD29) or β7, to form the VLA-4 (integrin α4β1) or LPAM-1 (integrin α4β7) complexes. CD49d plays a critical role in adhesion and T cell costimulation. The primary ligands for CD49d are VCAM-1, MAdCAM-1, and fibronectin.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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