PE/Dazzle™ 594 anti-mouse CD86 Antibody, CD86, A17199A,BioLegend,159210

Clone A17199A is able to completely block the binding of clone PO3 to CD86.

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB050642560

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePE/Dazzle™ 594 anti-mouse CD86 Antibody, CD86, A17199A
Cat. No.159210
HostRat
RRIDAB_3106037 (BioLegend Cat. No. 159209)AB_3106037 (BioLegend Cat. No. 159210)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberA17199A
Concentration0.2 mg/mL
TargetCD86
ImmunogenRecombinant mouse CD86
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes. CD86, along with CD80, is a ligand of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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