PE/Fire™ 640 anti-mouse CD278 (ICOS) Antibody, CD278, 15F9,BioLegend,107714

Additional reported applications (for the relevant formats) include: immunohistochemical staining2of acetone-fixed frozen sections.

Host

Syrian Hamster

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB416556952

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Contact

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Product Specifications
Scientific Background

Specifications

NamePE/Fire™ 640 anti-mouse CD278 (ICOS) Antibody, CD278, 15F9
Cat. No.107714
HostSyrian Hamster
RRIDAB_2924445 (BioLegend Cat. No. 107713)AB_2924445 (BioLegend Cat. No. 107714)
IsotypeSyrian Hamster IgG
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number15F9
Concentration0.2 mg/mL
TargetCD278
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Fire™ 640 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD278 is a 47-57 kD protein, also known as inducible costimulatory molecule (ICOS), or H4. This protein is homologous to the CD28/CTLA-4 proteins. It forms homodimers and is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2cell development. It has also been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.

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