PE/Fire™ 744 anti-human TIGIT (VSTM3) Antibody, TIGIT (VSTM3), A15153G,BioLegend,373747

This clone can suppress anti-CD3 induced T cell proliferationin vitrobased on in-house testing.This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of paraffin-embedded tissue sections (IHC-P).Additional reported applications (for the relevant formats) include: Blocking1.

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB984862885

BioLegend

Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NamePE/Fire™ 744 anti-human TIGIT (VSTM3) Antibody, TIGIT (VSTM3), A15153G
Cat. No.373747
HostMouse
RRIDAB_3699012 (BioLegend Cat. No. 373747)AB_3699012 (BioLegend Cat. No. 373748)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberA15153G
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetTIGIT
ImmunogenRecombinant Human TIGIT.
PurityThe antibody was purified by affinity chromatography and conjugated with PE/Fire™ 744 under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3 or WUCAM, is a 26 kD, type I transmembrane protein and is a member of the PVR (poliovirus receptor) family of immunoglobulin-like domain containing proteins. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. TIGIT is a negative regulator of NK and T cell activation. Expression of TIGIT is associated with decreased functionality of CD8 T cells in chronic viral infection and tumors. TIGIT also promotes the differentiation of tolerogenic phenotype in dendritic cells with an increased secretion of IL-10 and a diminished production of IL-12.

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