PE-Labeled Monoclonal Anti-Human CD95 Antibody, Mouse IgG1 (AS578) (0.03% Proclin),Acro Biosystems,FABm035-01
Host
Mouse
Conjugate
PE
Platform ID
BAB903444283
Acro Biosystems
Contact
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Product Specifications
Specifications
NamePE-Labeled Monoclonal Anti-Human CD95 Antibody, Mouse IgG1 (AS578) (0.03% Proclin)
Cat. No.FABm035-01
HostMouse
IsotypeMouse IgG1 | Mouse kappa
ConjugationPE
Clone NumberAS578
ImmunogenPurified Human CD95 Protein
FormulationSupplied as 0.2 μm-filtered solution in PBS (pH 7.4) containing 0.03% ProClin 300 and 0.2% BSA, with trehalose as protectant.
Please contact us for customized product forms or formulations.
StorageThe Fas is also known as FAS receptor (FasR), apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6). is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. FasR is located on chromosome 10 in humans and 19 in mice. Similar sequences related by evolution (orthologs) are found in most mammals. Fas forms the death-inducing signaling complex (DISC) upon ligand binding. Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes trimerization of Fas receptor. This event is also mimicked by binding of an agonistic Fas antibody, though some evidence suggests that the apoptotic signal induced by the antibody is unreliable in the study of Fas signaling. To this end, several clever ways of trimerizing the antibody for in vitro research have been employed.Upon ensuing death domain (DD) aggregation, the receptor complex is internalized via the cellular endosomal machinery. This allows the adaptor molecule FADD to bind the death domain of Fas through its own death domain. Recently, Fas has also been shown to promote tumor growth, since during tumor progression, it is frequently downregulated or cells are rendered apoptosis resistant. Cancer cells in general, regardless of their Fas apoptosis sensitivity, depend on constitutive activity of Fas. This is stimulated by cancer-produced Fas ligand for optimal growth.
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- Products>Primary Antibodies>Monoclonal Antibodies
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