PE Rabbit anti-Mouse CD152/CTLA-4 mAb,ABclonal,A27774

Reactivity

Mouse

Application

FC

Conjugate

PE. Ex:565nm. Em:574nm.

Platform ID

BAB376319953

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

Tel:
Fax:

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NamePE Rabbit anti-Mouse CD152/CTLA-4 mAb
Cat. No.A27774
RRID#N/A
IsotypeIgG
ReactivityMouse
ConjugationPE. Ex:565nm. Em:574nm.
ApplicationFC
Working DilutionsFC:≤0.25 µg per million cells in 100 µl volume
Clone NumberARC69140
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at 2-8℃. Avoid freeze.; Buffer: PBS with 0.09% Sodium azide, 0.2% BSA, pH7.3.
Regulatory StatusResearch Use Only

Scientific Background

CD152, also known as CTLA-4 or Ly-56, is a 33 kDa member of the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes. CD152 exhibits significant homology to CD28 in amino acid sequence, structural configuration, and genomic organization, with both receptors sharing ligands from the B7 family (B7-1 and B7-2). While CD28 delivers co-stimulatory signals during T cell activation, CTLA-4 functions as a critical negative regulator of cell-mediated immune responses. CD152 is implicated in the induction and maintenance of immune tolerance, the development of protective immunity, and the modulation of thymocyte homeostasis.

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