PE anti-NRF2 Antibody, NRF2, W19086B,BioLegend,939204
This clone was tested for ICC on 4% PFA-fixed HeLa cells and permeabilized with either methanol or Triton X-100. Both permeabilization methods were compatible with NRF2 staining.Clone W19086B is validated to detect NRF2 in mouse NIH/3T3 cells using a Western blot on whole cell lysate.
Host
Rat
Reactivity
Human
Application
ICFC – Quality tested
Platform ID
BAB520695677
BioLegend
Contact
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Product Specifications
Scientific Background
Specifications
NamePE anti-NRF2 Antibody, NRF2, W19086B
Cat. No.939204
HostRat
RRIDAB_2936521 (BioLegend Cat. No. 939203)AB_2936521 (BioLegend Cat. No. 939204)
IsotypeRat IgG2a, κ
ReactivityHuman
ApplicationICFC – Quality tested
ClonalityMonoclonal
Clone NumberW19086B
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetNRF2
ImmunogenPartial recombinant human NRF2 protein
PurityThe antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
NRF2 is a transcription factor that plays a critical role in inducing expression of genes required for oxidative stress defense and stress balance. It does so by binding to antioxidant response elements (AREs), which are located upstream of target genes. NRF2 is degraded by ubiquitination of KEAP1 E3 ligase. In a clinical setting, NRF2 is frequently activated in many types of cancers; it drives metabolic adaptation and survival in ROS-rich tumor microenvironments.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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