PE anti-human AXL Antibody, AXL, S21005B,BioLegend,386204

Clone S21005B recognizes a different epitope compared to clone S21005C.Clone S21005B can block GAS6 induced AKT and ERK phosphorylation in H1299 cells.

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB386237719

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Product Specifications
Scientific Background

Specifications

NamePE anti-human AXL Antibody, AXL, S21005B
Cat. No.386204
HostMouse
RRIDAB_3662285 (BioLegend Cat. No. 386203)AB_3662285 (BioLegend Cat. No. 386204)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberS21005B
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetAXL
PurityThe antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

AXL, also known as ARK or UFO, is a widely expressed glycoprotein in the TAM (Tyro3/Dtk, AXL, and Mer) receptor tyrosine kinase family. AXL is highly expressed in solid cancers. It is also expressed on a small population of human dendritic cells that share characteristics of classical and plasmacytoid dendritic cells. AXL binds the vitamin K-dependent growth arrest specific 6 (Gas6) protein and induces receptor autophosphorylation and downstream signaling pathways that are related to cell proliferation, migration, or apoptosis. AXL is also involved in hematopoiesis, embryonic development, tumorigenesis, and regulation of testicular functions. Recent studies have also shown that AXL and Mer are both linked to Alzheimer's disease

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