PE anti-human CCL22 Antibody, CCL22, A15083D,BioLegend,694408

Clones A15083A and A15083D do not block each otherClone A15083A does not block the reference clone T51-719 (BD Bioscience)Clones A15083A and A15083D showed good staining in both Cyto-Fast™ Fix/Perm Buffer Set and True-Phos™ Perm Buffer.

Host

Mouse

Reactivity

Human

Application

ICFC - Quality tested

Platform ID

BAB671756926

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Contact

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Product Specifications
Scientific Background

Specifications

NamePE anti-human CCL22 Antibody, CCL22, A15083D
Cat. No.694408
HostMouse
RRIDAB_3068170 (BioLegend Cat. No. 694407)AB_3068170 (BioLegend Cat. No. 694408)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationICFC - Quality tested
ClonalityMonoclonal
Clone NumberA15083D
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCCL22
ImmunogenHuman CCL22
PurityThe antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CCL22 is thymus-specific chemokine engaged in the recruitment of T cells. CCL22 is associated with different diseases such as allergen-induced lung inflammation, atopic dermatitis, and lymphoma. Also, high levels of CCL22 have been detected in the CNS in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). In addition, CCR4+ T cells have been linked to endotoxic shock, rheumatoid arthritis, T cell lymphoma, and autoimmune diabetes. CCL22 is a prostaglandin-dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue.

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