PE anti-human CD158b (KIR2DL2/KIR2DL3) Antibody, CD158b, S22037G,BioLegend,317509

CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.CD158b1 and CD158b2 are 38 kD two extracellular Ig domain glycoprotein that displays a long cytoplasmic tail with ITIM motifs. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR2DL2 and KIR2DL3 have been reported to bind to certain HLA-C antigens on a target cell (HLA-C*01, HLA-C*03, HLA-C*07, for example).