PE anti-human CD158b/j (KIR2DL2/L3/S2) Antibody, CD158b/j, S22038E,BioLegend,316811

CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and possess inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. Fifteen polymorphic KIR genes have been reported in humans.CD158b1, CD158b2, and CD158j are 33-38 kD two extracellular Ig domain glycoprotein that displays a long cytoplasmic tail with ITIM motifs for KIR2DL2/KIR2DL3 or a short cytoplasmic tail with an ITAM motif for KIR2DS2. It is expressed primarily on a subset of NK cells and a subset of T cells. KIR2DL2/KIR2DS2/KIR2DL3 has been reported to bind to certain HLA-C antigens on a target cell (HLA-C*01, HLA-C*03, HLA-C*07, for example).