PE anti-human CD202b Tie2 Tek Antibody, CD202b, A19069E,BioLegend,390554

Clone A19069E partially block the staining of reference clone 33.1​Recombinant protein completely blocks the staining of test clone A19069E

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB802116852

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Product Specifications
Scientific Background

Specifications

NamePE anti-human CD202b Tie2 Tek Antibody, CD202b, A19069E
Cat. No.390554
HostMouse
RRIDAB_3675121 (BioLegend Cat. No. 390553)AB_3675121 (BioLegend Cat. No. 390554)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberA19069E
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD202b
ImmunogenRecombinant extracellular domain of human Tie2
PurityThe antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD202b, also known as Tie2 or TEK, is a 145 kD type I transmembrane protein. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie2 binds to Ang-4 as well.

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