PE anti-human CD262 (DR5, TRAIL-R2) Antibody, CD262, A21121I,BioLegend,390706
Clone A21121I does not block the staining of reference clone DJR2-4 (7-8)Recombinant protein completely blocks the staining of test clone A21121I.
Host
Mouse
Reactivity
Human
Application
FC - Quality tested
Platform ID
BAB240984945
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePE anti-human CD262 (DR5, TRAIL-R2) Antibody, CD262, A21121I
Cat. No.390706
HostMouse
RRIDAB_3662287 (BioLegend Cat. No. 390705)AB_3662287 (BioLegend Cat. No. 390706)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberA21121I
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD262
ImmunogenRecombinant Human TNFRSF10B
PurityThe antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
DR5, also known as TRAIL-R2, TRICK2, KILLER, and CD262, is 55 kD member 10B of the TNF receptor superfamily (TNFRSF10B). It binds the cytotoxic ligand, TRAIL, and induces apoptosis. The DR5 receptor is broadly expressed on a variety of normal tissues and many tumors. DR5 expression has been reported to be upregulated in human cells by interferon-α, 2-methoxyestradiol, and paclitaxel, and downregulated by adenoviral E3 proteins.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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