PE anti-human CD35 Antibody anti-CD35 - E11,BioLegend,333406

Additional reported applications (for the relevant formats) include: spatial biology (IBEX)4,5.

Host

Mouse

Reactivity

Human

Application

FC - Quality testedSB - Reported in the literature, not verified in house

Platform ID

BAB283387111

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Product Specifications
Scientific Background

Specifications

NamePE anti-human CD35 Antibody anti-CD35 - E11
Cat. No.333406
HostMouse
RRIDAB_2085021 (BioLegend Cat. No. 333405)AB_2292231 (BioLegend Cat. No. 333406)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality testedSB - Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberE11
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD35
PurityThe antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD35 is a type I single chain of glycoprotein, also known as C3b/C4b receptor, Complement Receptor type 1 or CR1. Four molecular weight allotypes (160kD, 190kD, 220kD, and 250kD) have been described. CD35 is expressed on granulocytes, monocytes, B cells, erythrocytes, and follicular dendritic cells, as well as subsets of NK and T cells. CD35 binds complement C3b, C4b, or iC3, and iC4, and plays important roles in both innate and adoptive immune response via mediating phagocytosis by granulocytes and monocytes. CD35 has also been reported to inhibit T-cell proliferation.

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