PE anti-human CD66 (CEACAM4/6) Antibody, CD66, W20030D,BioLegend,387704

Clone W20030D binds both CEACAM4 and CEACAM6.

Host

Rat

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB397032535

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePE anti-human CD66 (CEACAM4/6) Antibody, CD66, W20030D
Cat. No.387704
HostRat
RRIDAB_2941578 (BioLegend Cat. No. 387703)AB_2941578 (BioLegend Cat. No. 387704)
IsotypeRat IgG2b, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberW20030D
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetCD66
ImmunogenRecombinant protein, aa 35-320
PurityThe antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CEACAM4, also known as CGM7, belongs to the immunoglobulin superfamily, specifically the carcinoembryonic antigen (CEA)-like subfamily. It is an orphan receptor that serves a phagocytic function in human granulocytes.CD66c, also known as CEACAM6, is one of the splice variants of CD66. It is expressed on endothelial, epithelial cells, neutrophils, monocytes, and myeloma and cancer cells, such as B-cell acute lymphoblastic lymphomas. CD66 expression level can be induced on T cells, B cells, and CD16-negative NK cells. Like the other CD66 splice variants, CD66c is involved in cell adhesion and growth, neutrophil activation, and signaling. It plays a role in hemophilic and heterophilic adhesion.

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