PE anti-human IL-16 Antibody anti-IL-16 - 14.1,BioLegend,519106

Additional reported applications (for the relevant formats) include: ELISA2, inhibition of T cell chemotaxis2and immunohistochemical staining of frozen lymph node sections3.

Host

Mouse

Reactivity

Human

Application

ICFC - Quality tested

Platform ID

BAB352576413

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Contact

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Product Specifications
Scientific Background

Specifications

NamePE anti-human IL-16 Antibody anti-IL-16 - 14.1
Cat. No.519106
HostMouse
RRIDAB_10897940 (BioLegend Cat. No. 519106)
IsotypeMouse IgG2a
ReactivityHuman
ApplicationICFC - Quality tested
ClonalityMonoclonal
Clone Number14.1
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetIL-16
ImmunogenPeptide corresponding to amino acids 615 to 630 (RRKSLQSKETTAAGDS) of IL-16
PurityThe antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Interleukin-16 is a proinflammatory cytokine synthesized as a 68 kD precursor molecule (pro-IL-16). After cleavage of pro-IL-16 by caspase-3, IL-16 is released as a 12 kD protein, but its biologic activities are exerted by a tetramer. IL-16 is a chemoattractant for CD4+T cells, monocytes, and eosinophils. On T cells, IL-16 upregulates CD25 and class II expression, and also inhibits HIV-1 replicationin vitroby repressing the transcription of the HIV-1 long terminal repeat. IL-16 is expressed by lymphocytes, macrophages, eosinophils, mast cells, epithelial cells, and fibroblasts. CD4 and CD9 are the receptors of IL-16.

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