PE anti-mouse CD262 (DR5, TRAIL-R2) Antibody, CD262, W18111A,BioLegend,118704
Host
Rat
Reactivity
Mouse
Application
FC - Quality tested
Platform ID
BAB643859059
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePE anti-mouse CD262 (DR5, TRAIL-R2) Antibody, CD262, W18111A
Cat. No.118704
HostRat
RRIDAB_3097165 (BioLegend Cat. No. 118703)AB_3097165 (BioLegend Cat. No. 118704)
IsotypeRat IgG2a, λ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberW18111A
Concentration0.2 mg/mL
TargetCD262
ImmunogenMouse DR5-Ig fusion protein
PurityThe antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
CD262, also known as DR5, TRAIL-R2, Apo-2, TRICK2, and KILLER, is a 55 kD protein. DR5 is member 10B of the TNF receptor superfamily (TNFRSF10B), widely expressed in normal tissues and some tumor cell lines. The DR5 receptor binds to TRAIL and interacts with the cytoplasmic proteins TRADD and RIP. TRAIL binding to DR5 activates NF- κB and induces apoptosis. DR5 is induced by wild-type p53.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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