PE anti-mouse PDC-TREM Antibody anti-PDC-TREM - 4A6,BioLegend,139203

Additional reported applications (for the relevant formats) include: Western blot1.

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB622591801

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NamePE anti-mouse PDC-TREM Antibody anti-PDC-TREM - 4A6
Cat. No.139203
HostRat
RRIDAB_10613646 (BioLegend Cat. No. 139203)AB_10613471 (BioLegend Cat. No. 139204)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number4A6
Concentration0.2 mg/ml
TargetPDC-TREM
ImmunogenRecombinant soluble PDC-TREM
PurityThe antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

PDC-TREM, also known as plasmacytoid dendritic cell (PDC) -specific receptor, is a member of the TREM receptor family. It is a transmembrane protein composed of an extracellular region with one V-type Ig domain, a transmembrane region with a lysine residue, and a cytoplasmic domain with no recognized signaling motifs. The lysine present in the transmembrane region allows PDC-TREM to form a complex with DAP12 and Plexin-A1. PI3K and Erk 1/2 are involved in the signal transduction of this complex. PDC-TREM is expressed in TLR-activated PDCs and is involved in the production of IFN-α.

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