PE anti-mouse PIR-A/B Antibody anti-PIR-A/B - 6C1,BioLegend,144104

Additional reported applications for the relevant formats include: Western Blotting1and immunohistochemical staining of frozen tissue sections3.

Host

Rat

Reactivity

Mouse

Application

FC - Quality tested

Platform ID

BAB257099735

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Contact

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Product Specifications
Scientific Background

Specifications

NamePE anti-mouse PIR-A/B Antibody anti-PIR-A/B - 6C1
Cat. No.144104
HostRat
RRIDAB_11203371 (BioLegend Cat. No. 144103)AB_11204242 (BioLegend Cat. No. 144104)
IsotypeRat IgG1, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone Number6C1
Concentration0.2 mg/ml
TargetPIR-A/B
ImmunogenRecombinant extracellular domains 1 and 2 of PIR-A
PurityThe antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Paired-immunoglobulin-like receptor (PIR) is a type I transmembrane protein, containing six Ig-like domains. Two isoforms (PIR-A and PIR-B) have been reported for this molecule. PIR-A/B is expressed on B cells, mast cells, macrophages, granulocytes, eosinophils, and dendritic cells. PIR-A requires association with FcRγc for its cell surface expression and to act as an activating receptor. The ligand for PIR-A is MHC class I. PIR-B is an inhibitory receptor with 3 ITIM motifs on its cytoplasmic tail; when phosphorylated, they recruit the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. MHC class I, Nogo, MAG, and OMgp are the ligands for PIR-B.

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