PE anti-mouse TLR4 CD284/MD2 Complex Antibody anti-CD284/MD2 - MTS510,BioLegend,117606
Anti-mouse TLR4 clones SA15-21 and MTS510 recognize distinct epitopes and don’t cross block each other.8Clone MTS510 binds to an epitope of TLR4/MD-2 that is lost after LPS stimulation.8In addition to flow cytometric uses, the MTS510 antibody has also been used for immunoprecipitation, immunofluorescence, and blocking of LPS-induced stimulation. The LEAF™ purified antibody (Endotoxin <0.1 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. No. 117607). For highly sensitive assays, we recommend Ultra-LEAF™ purified antibody (Cat. No. 117612) with a lower endotoxin limit than standard LEAF™ purified antibodies (Endotoxin <0.01 EU/µg).
Host
Rat
Reactivity
Mouse
Application
FC - Quality tested
Platform ID
BAB570294387
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePE anti-mouse TLR4 CD284/MD2 Complex Antibody anti-CD284/MD2 - MTS510
Cat. No.117606
HostRat
RRIDAB_313792 (BioLegend Cat. No. 117605)AB_2205138 (BioLegend Cat. No. 117606)
IsotypeRat IgG2a, κ
ReactivityMouse
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberMTS510
Concentration0.2 mg/ml
TargetTLR4 MD2 Complex
ImmunogenBa/F3 cell line transfected with mouse TLR4 /MD2 complex
PurityThe antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Regulatory StatusResearch Use Only
Scientific Background
Toll-like receptors are highly conserved from Drosophila to humans and share structural and functional similarities. They are type I transmembrane signaling receptors which activate the innate immune system in response to pathogen invasion. So far, at least 13 TLR members have been identified. The secretory protein, MD2, associates with cell-surface bound TLR4 (CD284) on monocytes, B cells and T cells. TLR4 has been recognized as critical for host recognition of bacterial LPS in conjunction with MD2.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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