PE anti-mouse/human CD282 (TLR2) Recombinant Antibody anti-CD282 - QA16A01,BioLegend,153004

Blocking of IL-6 and TNF-a production induced by P3CSK4on RAW264.7 cells was observed during development.

Host

Mouse

Reactivity

Mouse, Human

Application

FC -Quality tested

Platform ID

BAB374443383

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Product Specifications
Scientific Background

Specifications

NamePE anti-mouse/human CD282 (TLR2) Recombinant Antibody anti-CD282 - QA16A01
Cat. No.153004
HostMouse
RRIDAB_2728203 (BioLegend Cat. No. 153003)AB_2728204 (BioLegend Cat. No. 153004)
IsotypeMouse IgG1, κ
ReactivityMouse, Human
ApplicationFC -Quality tested
ClonalityRecombinant
Clone NumberQA16A01
Concentration0.2 mg/ml
TargetCD282
ImmunogenRecombinant extracellular domain of murine TLR2
PurityThe antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light.Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

CD282 (Toll-like receptor 2, TLR2) is an 85kDa, type I transmembrane protein, with 14 leucine-rich repeats (LRR) in the extracellular domain and a toll/IL-1R (TIR) in the cytoplasmic region. TLR2 is expressed by monocytes/macrophages, dendritic cells, granulocytes, endothelial cell and epithelial cells. TLR2 associates with TLR1 and TLR6 in the cell surface and is involved in the recognition of pathogen-associated molecular patterns (PAMPs) such as peptidoglycan, lipoteihoic acid (LTA), lipoarabinomanan, lipoproteins, and LPS from certain Gram-negative bacteria, yeast, spirochete and fungi.

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