PHD2/EGLN1 Rabbit pAb- ABclonal,ABclonal,A2314

Reactivity

Human

Application

IF/ICC, ELISA

Conjugate

Unconjugated

Platform ID

BAB101107061

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

Tel:
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Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NamePHD2/EGLN1 Rabbit pAb- ABclonal
Cat. No.A2314
RRID#N/A
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationIF/ICC, ELISA
Working DilutionsIF/ICC:1:50 - 1:200 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

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