PHD3 antibody,Genetex,GTX10880

Host

Rabbit

Reactivity

Human, Mouse, Rat, Primate

Application

WB ICC/IF IHC-P IP ChIP assay

Conjugate

Unconjugated

Platform ID

BAB185268024

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePHD3 antibody
Cat. No.GTX10880
Gene ID (Entrez)112399
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat, Primate
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P IP ChIP assay
ClonalityPolyclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetEGLN3
ImmunogenA synthetic peptide made to the C-terminus of humanPHD3/HIF Prolyl Hydroxylase 3. [LocusLink ID 112399]
PurityPurified by antigen-affinity chromatography
Appearance/FormLiquid
FormulationPBS,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism.

Synonyms

egl-9 family hypoxia inducible factor 3 , HIFP4H3 , HIFPH3 , PHD3

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