PIM2 antibody [10A12],Genetex,GTX83886

Host

Mouse

Reactivity

Human, Rat, Dog, Monkey

Application

WB IHC-P FCM

Conjugate

Unconjugated

Platform ID

BAB819542277

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePIM2 antibody [10A12]
Cat. No.GTX83886
Gene ID (Entrez)11040
HostMouse
IsotypeIgG2a
ReactivityHuman, Rat, Dog, Monkey
ConjugationUnconjugated
ApplicationWB IHC-P FCM
ClonalityMonoclonal
Concentration0.84 mg/ml (Please refer to the vial label for the specific concentration.)
TargetPIM2
ImmunogenFull length human recombinant protein of human PIM2 (NP_006866) produced in HEK293T cell.
PurityPurified by affinity chromatography
Appearance/FormLiquid
FormulationPBS, 1% BSA, 50% Glycerol,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappaB kinase/NF-kappaB cascade | this process requires phosphorylation of MAP3K8/COT. Prevents apoptosis induced by growth factor withdrawal via inhibition of caspase-3 activation, and via phosphorylation of pro-apoptotic proteins. Inhibits BAD-induced cell death via phosphorylation of BAD. PIM2-mediated cell survival is glucose-dependent but independent of several AKT regulators such as PI3K, HSP-90 and TOR, indicating that PIM2 and PI3K/AKT/TOR function via distinct pathways. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

Synonyms

Pim-2 proto-oncogene, serine/threonine kinase

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