PINK1 (D8G3) Rabbit Monoclonal Antibody#6946,Cell Signaling Technology (CST),6946

PINK1 (D8G3) Rabbit Monoclonal Antibody recognizes endogenous levels of total PINK1 protein.

Host

Rabbit

Reactivity

Human

Application

Western Blotting: 1:1000 Immunoprecipitation: 1:50

Platform ID

BAB689614557

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePINK1 (D8G3) Rabbit Monoclonal Antibody#6946
Cat. No.6946
Accession NumberQ9BXM7
Gene ID (Entrez)65018
HostRabbit
SensitivityEndogenous
ReactivityHuman
ApplicationWestern Blotting: 1:1000 Immunoprecipitation: 1:50
Molecular Weight60, 50
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

PTEN induced putative kinase 1, PINK1, is a mitochondrial serine/threonine kinase involved in the normal function and integrity of mitochondria, as well as in reduction of cytochrome c release from mitochondria (1-3). PINK1 phosphorylates Parkin and promotes its translocation to mitochondria (2). Research studies have shown that mutations inPINK1are linked to autosomal recessive early onset Parkinson’s disease, and are associated with loss of protective function, mitochondrial dysfunction, aggregation of α-synuclein, as well as proteasome dysfunction (1,3).Liu, W. et al. (2009)PLoS One4, e4597.Kim, Y. et al. (2008)Biochem Biophys Res Commun377, 975-80.Petit, A. et al. (2005)J Biol Chem280, 34025-32.Alternate NamesBRPK; FLJ27236; PARK6; PINK1; protein kinase BRPK; PTEN induced kinase 1; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial

Synonyms

BRPK; FLJ27236; PARK6; PINK1; protein kinase BRPK; PTEN induced kinase 1; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.