PKMYT1 antibody [2B4],Genetex,GTX83875

Host

Mouse

Reactivity

Human, Mouse, Rat, Dog, Monkey

Application

WB ICC/IF FCM

Conjugate

Unconjugated

Platform ID

BAB257011042

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePKMYT1 antibody [2B4]
Cat. No.GTX83875
Gene ID (Entrez)9088
HostMouse
IsotypeIgG2a
ReactivityHuman, Mouse, Rat, Dog, Monkey
ConjugationUnconjugated
ApplicationWB ICC/IF FCM
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetPKMYT1
ImmunogenFull length human recombinant protein of human PKMYT1 (NP_004194) produced in HEK293T cell.
PurityPurified by affinity chromatographyFrom tissue culture supernatant
Appearance/FormLiquid
FormulationPBS, 1% BSA, 50% Glycerol,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Synonyms

protein kinase, membrane associated tyrosine/threonine 1 , MYT1 , PPP1R126

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