PLCG2 (phospho Tyr753) antibody,Genetex,GTX38559

Host

Rabbit

Reactivity

Human

Application

WB ICC/IF

Conjugate

Unconjugated

Platform ID

BAB772176288

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePLCG2 (phospho Tyr753) antibody
Cat. No.GTX38559
Gene ID (Entrez)5336
HostRabbit
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB ICC/IF
ClonalityPolyclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetPLCG2
ImmunogenThe antiserum was produced against synthesized phosphopeptide derived from human PLC gamma 2 around the phosphorylation site of tyrosine 753 (S -L-Y(p)-D-V).
PurityPurified by antigen-affinity chromatography
Appearance/FormLiquid
FormulationPBS, 150mM NaCl, 50% Glycerol,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]

Synonyms

phospholipase C gamma 2 , APLAID , FCAS3 , PLC-IV , PLC-gamma-2

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