PLP1 Antibody#85971,Cell Signaling Technology (CST),85971

PLP1 Antibody recognizes endogenous levels of total PLP1 protein.

Reactivity

Human, Mouse, Rat

Application

Western Blotting: 1:1000

Platform ID

BAB877558094

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NamePLP1 Antibody#85971
Cat. No.85971
Accession NumberP60201
Gene ID (Entrez)60201, 5354
SensitivityEndogenous
ReactivityHuman, Mouse, Rat
ApplicationWestern Blotting: 1:1000
Molecular Weight20-30
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody
Regulatory StatusResearch Use Only

Scientific Background

Myelin proteolipid protein (PLP1) corresponds to the majority of myelin proteins in the CNS, providing support to axons and modulating the axonal growth (1). DM20 is the result of the alternative splicing of theplp1gene, which is linked to oligodendrocyte differentiation and survival. The imbalance of PLP1/DM20 is linked to Pelizaeus-Merzbacher disease (2,3), including mitochondrial damage (4). In addition, PLP1, but not DM20, can enter the mitochondria and participate in the metabolism of cells (5).Thomson, C.E. et al.Dev Neurosci27, 27-36.Laššuthová, P. et al. (2014)J Child Neurol29, 924-31.Dhaunchak, A.S. et al. (2011)J Neurosci31, 14961-71.Ruiz, M. et al. (2017)Brain Pathol28, 611-630. doi: 10.1111/bpa.12571. Epub 2017 Dec 26.Somayajulu, M. et al. (2018)Neurosci Lett678, 90-8.Alternate NamesGPM6C; HLD1; Lipophilin; major myelin proteolipid protein; MMPL; Myelin proteolipid protein; MYPR; PLP; PLP/DM20; PLP1; PMD; proteolipid protein 1; SPG2

Synonyms

GPM6C; HLD1; Lipophilin; major myelin proteolipid protein; MMPL; Myelin proteolipid protein; MYPR; PLP; PLP/DM20; PLP1; PMD; proteolipid protein 1; SPG2

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