PathScan^®RP LAG3 Sandwich ELISA Kit II#24631,Cell Signaling Technology (CST),24631

Lymphocyte activation gene 3 (LAG3, CD223) is an immune checkpoint control protein that negatively regulates T cells and immune responses. A CD4-like member of the Ig superfamily, LAG3 contains an extracellular IgV and three IgC domains, a transmembrane domain, and a short cytoplasmic region (1). LAG3 is primarily expressed by activated CD4+T cells, CD8+T cells, Tregs, and NK cells, where it's activated by MHC Class II molecules, its only known ligand. While it was initially shown to activate Treg cells (2), LAG3 can also inhibit CD8+T cells (3,4). LAG3 is often co-expressed with PD-1 on the surface of tumor infiltrating lymphocytes, where the two proteins act independently to contribute to tumor-mediated immune suppression (4,5). Blockade of LAG3 is a promising strategy for neoplastic intervention (6).Triebel, F. et al. (1990)J Exp Med171, 1393-405.Huang, C.T. et al. (2004)Immunity21, 503-13.Grosso, J.F. et al. (2007)J Clin Invest117, 3383-92.Woo, S.R. et al. (2012)Cancer Res72, 917-27.Matsuzaki, J. et al. (2010)Proc Natl Acad Sci U S A107, 7875-80.Goldberg, M.V. and Drake, C.G. (2011)Curr Top Microbiol Immunol344, 269-78.Alternate NamesActivation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; LAG; LAG-3; Lag3; Ly6; Ly66; Lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; OTTMUSP00000029126; Secreted lymphocyte activation gene 3 protein; sLAG-3

Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; LAG; LAG-3; Lag3; Ly6; Ly66; Lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; OTTMUSP00000029126; Secreted lymphocyte activation gene 3 protein; sLAG-3